Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium/hydrogen exchanger 1 (Rattus norvegicus) | BDBM50353115 (CHEMBL1829127) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.0680 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of NHE1 in Sprague-Dawley rat assessed as inhibition of acid-induced platelet swelling by spectrophotometric analysis | Eur J Med Chem 46: 4107-16 (2011) Article DOI: 10.1016/j.ejmech.2011.06.011 BindingDB Entry DOI: 10.7270/Q27081T0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/hydrogen exchanger 1 (Rattus norvegicus) | BDBM50353110 (CHEMBL1829122) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.0730 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of NHE1 in Sprague-Dawley rat assessed as inhibition of acid-induced platelet swelling by spectrophotometric analysis | Eur J Med Chem 46: 4107-16 (2011) Article DOI: 10.1016/j.ejmech.2011.06.011 BindingDB Entry DOI: 10.7270/Q27081T0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/hydrogen exchanger 1 (Rattus norvegicus) | BDBM50353113 (CHEMBL1829125) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.0840 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of NHE1 in Sprague-Dawley rat assessed as inhibition of acid-induced platelet swelling by spectrophotometric analysis | Eur J Med Chem 46: 4107-16 (2011) Article DOI: 10.1016/j.ejmech.2011.06.011 BindingDB Entry DOI: 10.7270/Q27081T0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/hydrogen exchanger 1 (Rattus norvegicus) | BDBM50353114 (CHEMBL1829126) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.0910 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of NHE1 in Sprague-Dawley rat assessed as inhibition of acid-induced platelet swelling by spectrophotometric analysis | Eur J Med Chem 46: 4107-16 (2011) Article DOI: 10.1016/j.ejmech.2011.06.011 BindingDB Entry DOI: 10.7270/Q27081T0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/hydrogen exchanger 1 (Rattus norvegicus) | BDBM50353111 (CHEMBL1829123) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.110 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of NHE1 in Sprague-Dawley rat assessed as inhibition of acid-induced platelet swelling by spectrophotometric analysis | Eur J Med Chem 46: 4107-16 (2011) Article DOI: 10.1016/j.ejmech.2011.06.011 BindingDB Entry DOI: 10.7270/Q27081T0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/hydrogen exchanger 1 (Rattus norvegicus) | BDBM50353097 (CHEMBL1829132) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.310 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of NHE1 in Sprague-Dawley rat assessed as inhibition of acid-induced platelet swelling by spectrophotometric analysis | Eur J Med Chem 46: 4107-16 (2011) Article DOI: 10.1016/j.ejmech.2011.06.011 BindingDB Entry DOI: 10.7270/Q27081T0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/hydrogen exchanger 1 (Homo sapiens (Human)) | BDBM50201454 (CHEMBL392093 | N-(diaminomethylene)-5-(2,5-dichlor...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.480 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Research Institute of Chemical Technology Curated by ChEMBL | Assay Description Inhibition of human NHE1 expressed in PS120 cells | Bioorg Med Chem Lett 17: 1291-5 (2007) Article DOI: 10.1016/j.bmcl.2006.12.012 BindingDB Entry DOI: 10.7270/Q2MW2GS1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/hydrogen exchanger 1 (Rattus norvegicus) | BDBM50353116 (CHEMBL1829128) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.530 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of NHE1 in Sprague-Dawley rat assessed as inhibition of acid-induced platelet swelling by spectrophotometric analysis | Eur J Med Chem 46: 4107-16 (2011) Article DOI: 10.1016/j.ejmech.2011.06.011 BindingDB Entry DOI: 10.7270/Q27081T0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/hydrogen exchanger 1 (Rattus norvegicus) | BDBM50353098 (CHEMBL1829133) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.560 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of NHE1 in Sprague-Dawley rat assessed as inhibition of acid-induced platelet swelling by spectrophotometric analysis | Eur J Med Chem 46: 4107-16 (2011) Article DOI: 10.1016/j.ejmech.2011.06.011 BindingDB Entry DOI: 10.7270/Q27081T0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/hydrogen exchanger 1 (Rattus norvegicus) | BDBM50353103 (CHEMBL1829139) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.670 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of NHE1 in Sprague-Dawley rat assessed as inhibition of acid-induced platelet swelling by spectrophotometric analysis | Eur J Med Chem 46: 4107-16 (2011) Article DOI: 10.1016/j.ejmech.2011.06.011 BindingDB Entry DOI: 10.7270/Q27081T0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/hydrogen exchanger 1 (Rattus norvegicus) | BDBM50353102 (CHEMBL1829138) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.920 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of NHE1 in Sprague-Dawley rat assessed as inhibition of acid-induced platelet swelling by spectrophotometric analysis | Eur J Med Chem 46: 4107-16 (2011) Article DOI: 10.1016/j.ejmech.2011.06.011 BindingDB Entry DOI: 10.7270/Q27081T0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/hydrogen exchanger 1 (Rattus norvegicus) | BDBM50378116 (CHEMBL1202327) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.940 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of NHE1 in Sprague-Dawley rat platelet-rich plasma by optical swelling assay | Eur J Med Chem 44: 3771-6 (2009) Article DOI: 10.1016/j.ejmech.2009.04.036 BindingDB Entry DOI: 10.7270/Q2474BS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/hydrogen exchanger 1 (Rattus norvegicus) | BDBM50353105 (CHEMBL1829117) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.06 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of NHE1 in Sprague-Dawley rat assessed as inhibition of acid-induced platelet swelling by spectrophotometric analysis | Eur J Med Chem 46: 4107-16 (2011) Article DOI: 10.1016/j.ejmech.2011.06.011 BindingDB Entry DOI: 10.7270/Q27081T0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/hydrogen exchanger 1 (Rattus norvegicus) | BDBM50353099 (CHEMBL1829134) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of NHE1 in Sprague-Dawley rat assessed as inhibition of acid-induced platelet swelling by spectrophotometric analysis | Eur J Med Chem 46: 4107-16 (2011) Article DOI: 10.1016/j.ejmech.2011.06.011 BindingDB Entry DOI: 10.7270/Q27081T0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/hydrogen exchanger 1 (Rattus norvegicus) | BDBM50297583 (CHEMBL560806 | N''-[2-(1H-benzimidazol-2-ylthio)-5...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.17 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of NHE1 in Sprague-Dawley rat platelet-rich plasma by optical swelling assay | Eur J Med Chem 44: 3771-6 (2009) Article DOI: 10.1016/j.ejmech.2009.04.036 BindingDB Entry DOI: 10.7270/Q2474BS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/hydrogen exchanger 1 (Rattus norvegicus) | BDBM50207580 (CHEMBL234074 | N-[3-(5-nitro-1H-benzoimidazol-2-yl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.42 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of NHE1 in rat platelets by Platelet swelling assay | Bioorg Med Chem Lett 17: 2430-3 (2007) Article DOI: 10.1016/j.bmcl.2007.02.035 BindingDB Entry DOI: 10.7270/Q21C1WJ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/hydrogen exchanger 1 (Rattus norvegicus) | BDBM50353101 (CHEMBL1829137) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of NHE1 in Sprague-Dawley rat assessed as inhibition of acid-induced platelet swelling by spectrophotometric analysis | Eur J Med Chem 46: 4107-16 (2011) Article DOI: 10.1016/j.ejmech.2011.06.011 BindingDB Entry DOI: 10.7270/Q27081T0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/hydrogen exchanger 1 (Rattus norvegicus) | BDBM50297577 (CHEMBL549392 | N''-[2-(1H-benzimidazol-2-ylthio)-2...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.73 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of NHE1 in Sprague-Dawley rat platelet-rich plasma by optical swelling assay | Eur J Med Chem 44: 3771-6 (2009) Article DOI: 10.1016/j.ejmech.2009.04.036 BindingDB Entry DOI: 10.7270/Q2474BS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/hydrogen exchanger 1 (Rattus norvegicus) | BDBM50297571 (CHEMBL561343 | N''-{2-[(5-nitro-1H-benzimidazol-2-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.74 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of NHE1 in Sprague-Dawley rat platelet-rich plasma by optical swelling assay | Eur J Med Chem 44: 3771-6 (2009) Article DOI: 10.1016/j.ejmech.2009.04.036 BindingDB Entry DOI: 10.7270/Q2474BS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/hydrogen exchanger 1 (Rattus norvegicus) | BDBM50345911 (CHEMBL1783852 | CHEMBL1789669 | N-(diaminomethylen...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.82 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of NHE1 in Sprague-Dawley rat assessed as inhibition of acid-induced platelet swelling by spectrophotometric analysis | Eur J Med Chem 46: 4107-16 (2011) Article DOI: 10.1016/j.ejmech.2011.06.011 BindingDB Entry DOI: 10.7270/Q27081T0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/hydrogen exchanger 1 (Rattus norvegicus) | BDBM50297563 (CHEMBL550813 | N''-[2-(1,3-benzothiazol-2-ylthio)-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of NHE1 in Sprague-Dawley rat platelet-rich plasma by optical swelling assay | Eur J Med Chem 44: 3771-6 (2009) Article DOI: 10.1016/j.ejmech.2009.04.036 BindingDB Entry DOI: 10.7270/Q2474BS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/hydrogen exchanger 1 (Rattus norvegicus) | BDBM50297578 (2-{[(1E)-2-(1,3-benzothiazol-2-ylsulfanyl)-4,5,6-t...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.98 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of NHE1 in Sprague-Dawley rat platelet-rich plasma by optical swelling assay | Eur J Med Chem 44: 3771-6 (2009) Article DOI: 10.1016/j.ejmech.2009.04.036 BindingDB Entry DOI: 10.7270/Q2474BS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/hydrogen exchanger 1 (Rattus norvegicus) | BDBM50297580 (CHEMBL560884 | N''-[2-(1,3-benzothiazol-2-ylthio)-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.34 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of NHE1 in Sprague-Dawley rat platelet-rich plasma by optical swelling assay | Eur J Med Chem 44: 3771-6 (2009) Article DOI: 10.1016/j.ejmech.2009.04.036 BindingDB Entry DOI: 10.7270/Q2474BS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/hydrogen exchanger 1 (Rattus norvegicus) | BDBM50297562 (CHEMBL563178 | N''-[2-(1,3-benzothiazol-2-ylthio)-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.44 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of NHE1 in Sprague-Dawley rat platelet-rich plasma by optical swelling assay | Eur J Med Chem 44: 3771-6 (2009) Article DOI: 10.1016/j.ejmech.2009.04.036 BindingDB Entry DOI: 10.7270/Q2474BS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/hydrogen exchanger 1 (Homo sapiens (Human)) | BDBM50104843 (CHEMBL419578 | N-[3-(3-Bromo-4-fluoro-phenyl)-2,2-...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Screened in AP1 cells expressing human NHE-1 for sodium hydrogen exchange activity | J Med Chem 44: 3302-10 (2001) BindingDB Entry DOI: 10.7270/Q2H41QQ4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/hydrogen exchanger 1 (Rattus norvegicus) | BDBM50345911 (CHEMBL1783852 | CHEMBL1789669 | N-(diaminomethylen...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of NHE1-mediated rat platelet swelling | Bioorg Med Chem Lett 19: 3283-7 (2009) Article DOI: 10.1016/j.bmcl.2009.04.079 BindingDB Entry DOI: 10.7270/Q2BR8SJ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/hydrogen exchanger 1 (Rattus norvegicus) | BDBM50207583 (CHEMBL234279 | N-[2-(5-nitro-1H-benzoimidazol-2-yl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.05 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of NHE1 in rat platelets by Platelet swelling assay | Bioorg Med Chem Lett 17: 2430-3 (2007) Article DOI: 10.1016/j.bmcl.2007.02.035 BindingDB Entry DOI: 10.7270/Q21C1WJ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/hydrogen exchanger 1 (Rattus norvegicus) | BDBM50345917 (CHEMBL1783857 | N-(diaminomethylene)-3-(N-methylsu...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.48 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of NHE1-mediated rat platelet swelling | Bioorg Med Chem Lett 19: 3283-7 (2009) Article DOI: 10.1016/j.bmcl.2009.04.079 BindingDB Entry DOI: 10.7270/Q2BR8SJ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/hydrogen exchanger 1 (Homo sapiens (Human)) | BDBM50191852 (2-(5-(4-fluoro-3-methylphenyl)-4-(4-(4-methyl-1H-i...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of human NHE1 expressed in Ap1 cell line | Bioorg Med Chem Lett 16: 4796-9 (2006) Article DOI: 10.1016/j.bmcl.2006.06.077 BindingDB Entry DOI: 10.7270/Q2DN44P1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/hydrogen exchanger 1 (Homo sapiens (Human)) | BDBM50396463 (CHEMBL2170611) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of NHE1 in human HT-29 cells assessed as intracellular pH change after 30 mins | J Med Chem 55: 7114-40 (2012) Article DOI: 10.1021/jm300601d BindingDB Entry DOI: 10.7270/Q2FB5430 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/hydrogen exchanger 1 (Homo sapiens (Human)) | BDBM50104846 (CHEMBL113443 | N-[3-(2,5-Dichloro-phenyl)-2,2-dime...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Screened in AP1 cells expressing human NHE-1 for sodium hydrogen exchange activity | J Med Chem 44: 3302-10 (2001) BindingDB Entry DOI: 10.7270/Q2H41QQ4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/hydrogen exchanger 1 (Homo sapiens (Human)) | BDBM50104848 (CHEMBL112903 | N-[3-(3-Ethyl-4-fluoro-phenyl)-2,2-...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Screened in AP1 cells expressing human NHE-1 for sodium hydrogen exchange activity | J Med Chem 44: 3302-10 (2001) BindingDB Entry DOI: 10.7270/Q2H41QQ4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/hydrogen exchanger 1 (Homo sapiens (Human)) | BDBM50191839 (5-(1-(5-(3-chloro-4-fluorophenyl)pyrimidin-4-yl)pi...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 5.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of human NHE1 expressed in Ap1 cell line | Bioorg Med Chem Lett 16: 4796-9 (2006) Article DOI: 10.1016/j.bmcl.2006.06.077 BindingDB Entry DOI: 10.7270/Q2DN44P1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/hydrogen exchanger 1 (Homo sapiens (Human)) | BDBM50396469 (CHEMBL2170610) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of NHE1 in human HT-29 cells assessed as intracellular pH change after 30 mins | J Med Chem 55: 7114-40 (2012) Article DOI: 10.1021/jm300601d BindingDB Entry DOI: 10.7270/Q2FB5430 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/hydrogen exchanger 1 (Homo sapiens (Human)) | BDBM50104856 (CHEMBL51363 | N-[(1R,3S)-3-(3,5-Dichloro-phenyl)-2...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Screened in AP1 cells expressing human NHE-1 for sodium hydrogen exchange activity | J Med Chem 44: 3302-10 (2001) BindingDB Entry DOI: 10.7270/Q2H41QQ4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/hydrogen exchanger 1 (Homo sapiens (Human)) | BDBM50104856 (CHEMBL51363 | N-[(1R,3S)-3-(3,5-Dichloro-phenyl)-2...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of sodium dependent recovery of pH following imposed acidosis in AP1 cell line expressing the human NHE-1 isoform. | Bioorg Med Chem Lett 14: 177-80 (2003) BindingDB Entry DOI: 10.7270/Q2NC60MN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/hydrogen exchanger 1 (Homo sapiens (Human)) | BDBM50191831 (5-(4-fluoro-3-methylphenyl)-2-methoxy-4-(4-(4-meth...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 6.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of human NHE1 expressed in Ap1 cell line | Bioorg Med Chem Lett 16: 4796-9 (2006) Article DOI: 10.1016/j.bmcl.2006.06.077 BindingDB Entry DOI: 10.7270/Q2DN44P1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/hydrogen exchanger 1 (Homo sapiens (Human)) | BDBM50191846 (5-(4-fluoro-3-methylphenyl)-2-isopropoxy-4-(4-(4-m...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 7.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of human NHE1 expressed in Ap1 cell line | Bioorg Med Chem Lett 16: 4796-9 (2006) Article DOI: 10.1016/j.bmcl.2006.06.077 BindingDB Entry DOI: 10.7270/Q2DN44P1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/hydrogen exchanger 1 (Homo sapiens (Human)) | BDBM50137552 (5-[(1R,3S)-3-(3,5-Dichloro-phenyl)-2,2-dimethyl-cy...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of sodium dependent recovery of pH following imposed acidosis in AP1 cell line expressing the human NHE-1 isoform. | Bioorg Med Chem Lett 14: 177-80 (2003) BindingDB Entry DOI: 10.7270/Q2NC60MN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/hydrogen exchanger 1 (Homo sapiens (Human)) | BDBM50201465 (3-amino-N-(diaminomethylene)-5-(2,5-dichlorophenyl...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Research Institute of Chemical Technology Curated by ChEMBL | Assay Description Inhibition of human NHE1 expressed in PS120 cells | Bioorg Med Chem Lett 17: 1291-5 (2007) Article DOI: 10.1016/j.bmcl.2006.12.012 BindingDB Entry DOI: 10.7270/Q2MW2GS1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/hydrogen exchanger 1 (Homo sapiens (Human)) | BDBM50201443 (CHEMBL395897 | N-(diaminomethylene)-5-(2,5-dichlor...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Research Institute of Chemical Technology Curated by ChEMBL | Assay Description Inhibition of human NHE1 expressed in PS120 cells | Bioorg Med Chem Lett 17: 1291-5 (2007) Article DOI: 10.1016/j.bmcl.2006.12.012 BindingDB Entry DOI: 10.7270/Q2MW2GS1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/hydrogen exchanger 1 (Homo sapiens (Human)) | BDBM50104844 (BMS-284640 | CHEMBL51879 | N-[(1R,3R)-3-(2,3-Dihyd...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of sodium dependent recovery of pH following imposed acidosis in AP1 cell line expressing the human NHE-1 isoform. | Bioorg Med Chem Lett 14: 177-80 (2003) BindingDB Entry DOI: 10.7270/Q2NC60MN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/hydrogen exchanger 1 (Homo sapiens (Human)) | BDBM50104844 (BMS-284640 | CHEMBL51879 | N-[(1R,3R)-3-(2,3-Dihyd...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Screened in AP1 cells expressing human NHE-1 for sodium hydrogen exchange activity | J Med Chem 44: 3302-10 (2001) BindingDB Entry DOI: 10.7270/Q2H41QQ4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/hydrogen exchanger 1 (Homo sapiens (Human)) | BDBM50104844 (BMS-284640 | CHEMBL51879 | N-[(1R,3R)-3-(2,3-Dihyd...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences , St. John's University , Queens , New York 11439 , United States. Curated by ChEMBL | Assay Description Inhibition of human NHE1 by cell based assay | J Med Chem 61: 2166-2210 (2018) Article DOI: 10.1021/acs.jmedchem.7b00315 BindingDB Entry DOI: 10.7270/Q2B56N68 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/hydrogen exchanger 1 (Homo sapiens (Human)) | BDBM50396471 (CHEMBL2170608) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of NHE1 in human HT-29 cells assessed as intracellular pH change after 30 mins | J Med Chem 55: 7114-40 (2012) Article DOI: 10.1021/jm300601d BindingDB Entry DOI: 10.7270/Q2FB5430 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/hydrogen exchanger 1 (Homo sapiens (Human)) | BDBM50201470 (5-(5-chloro-2-methoxyphenyl)-N-(diaminomethylene)-...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Research Institute of Chemical Technology Curated by ChEMBL | Assay Description Inhibition of human NHE1 expressed in PS120 cells | Bioorg Med Chem Lett 17: 1291-5 (2007) Article DOI: 10.1016/j.bmcl.2006.12.012 BindingDB Entry DOI: 10.7270/Q2MW2GS1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/hydrogen exchanger 1 (Rattus norvegicus) | BDBM50297575 (2-{[(1E)-2-(1H-1,3-benzodiazol-2-ylsulfanyl)-4,5,6...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 10.8 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of NHE1 in Sprague-Dawley rat platelet-rich plasma by optical swelling assay | Eur J Med Chem 44: 3771-6 (2009) Article DOI: 10.1016/j.ejmech.2009.04.036 BindingDB Entry DOI: 10.7270/Q2474BS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/hydrogen exchanger 1 (Homo sapiens (Human)) | BDBM50396470 (CHEMBL2170609) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of NHE1 in human HT-29 cells assessed as intracellular pH change after 30 mins | J Med Chem 55: 7114-40 (2012) Article DOI: 10.1021/jm300601d BindingDB Entry DOI: 10.7270/Q2FB5430 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/hydrogen exchanger 1 (Rattus norvegicus) | BDBM50207572 (CHEMBL234072 | N-[4-(5-nitro-1H-benzoimidazol-2-yl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of NHE1 in rat platelets by Platelet swelling assay | Bioorg Med Chem Lett 17: 2430-3 (2007) Article DOI: 10.1016/j.bmcl.2007.02.035 BindingDB Entry DOI: 10.7270/Q21C1WJ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/hydrogen exchanger 1 (Rattus norvegicus) | BDBM50345908 (CHEMBL1783849 | N-(diaminomethylene)-2-((4-(2,3,4-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 11.1 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of NHE1-mediated rat platelet swelling | Bioorg Med Chem Lett 19: 3283-7 (2009) Article DOI: 10.1016/j.bmcl.2009.04.079 BindingDB Entry DOI: 10.7270/Q2BR8SJ1 | |||||||||||
More data for this Ligand-Target Pair |
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